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Salvage bed in radiation island7/9/2023 Roy S, Loblaw A, Cheung P et al (2019) Prostate-specific antigen bounce after stereotactic body radiotherapy for prostate cancer: a pooled analysis of four prospective trials. Int J Radiat Oncol Biol Phys 80(3):735–741 Epub 2010 Jun 18Īkyol F, Ozyigit G, Selek U et al (2005) PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone. Urology 76:728–733Ĭaloglu M, Ciezki JP, Reddy CA et al (2011) PSA bounce and biochemical failure after brachytherapy for prostate cancer: a study of 820 patients with a minimum of 3 years of follow-up. Sheinbein C, Teh BS, Mai WY et al (2010) Prostate-specific antigen bounce after intensity-modulated radiotherapy for prostate cancer. It highlights the importance of serial PSA monitoring to confirm biochemical relapse before committing the patient to androgen deprivation therapy (with its inherent risks and side effects). To our knowledge, this is the first case published describing the effect in the post-prostatectomy setting. ![]() ![]() This PSA ‘bounce phenomenon’ is well described following radiotherapy to an intact prostate and has been proposed to be the result of a late fibrotic effect on irradiated prostate tissue. Following undetectable results (<0.03 μg/L), his PSA rose from 0.04 to 0.3 μg/L with no evidence of prostate cancer recurrence before returning to undetectable levels without medical intervention. We present a case of prostate-specific antigen (PSA) bounce in a 76 year old man who underwent salvage radiotherapy to the prostate bed following biochemical relapse 6 years post-radical prostatectomy for a T2N0 Gleason grade 3 + 3 prostate adenocarcinoma 10 months following completion of salvage radiotherapy for biochemical PSA recurrence of 0.2 μg/L.
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